职称：副研究员（校聘）

学历：理学博士

QQ：937351462

电子邮箱：longbin_z@163.com

研究方向：蛋白质与酶工程、基因调控、组学研究

教育工作经历：

2020-至今 bet356体育亚洲官网入口       副研究员(校聘) / 福建省C类人才

2016-2020    华侨大学医学院                讲师

2011-2016    浙江大学                    微生物学博士

2007-2011    福建师范大学                 生物技术学士

承担课程：

1、 本科生：生物化学；有机化学；分子生物学；细胞生物学实验

2、 研究生：酶工程及其应用

3、 校公选课：人类健康与现代医学

科研简介：

1、 微生物发酵产酶（漆酶、褐藻胶裂解酶等）及其工业化运用的研究；

2、 微生物功能性代谢物（寡聚糖、羟基喹啉醌等）的生产与应用；

3、 微生物组学的生物信息分析（转录组、代谢组、蛋白组、宏基因组等；

4、 昆虫病源真菌的基因功能及调控机理研究；

社会兼职：

转化医学杂志青年编委

科研项目：

1、 福建省自然科学基金面上项目：Sur7介导多代谢通路影响球孢白僵菌生防潜能的机制研究。（2021-2024年，10万，主持）

2、 福州大学人才项目：基于转录组与代谢组分析Sur7调控球孢白僵菌生长的分子机理。（2020-2022年，10万，主持）

3、 福州大学2022年贵重仪器设备开放测试基金：漆酶催化生物活性物质的聚合反应。（2022.1.1-2022.12.31，0.5万，主持）

4、 国家自然科学基金面上项目：多组学联合解析BbRho4调控球孢白僵菌生长及抗氧化力的分子机制。（2021-2024年，69.6万，参与）

5、 国家自然科学基金青年项目：MicroRNA对大脑皮层神经发生的反馈环路调控机制。（2018-2020年，20万，主持）

6、 福建省自然科学基金青年创新项目：MicroRNA-26对大脑皮层神经发生的反馈环路调控机制。（2018-2021年，4万，主持）

代表性论文：(#共同第一作者；*为通讯作者)

1. Zhang BL^*, Qiu TT, Guan Y, Huang ZH, Ye XY. Analyses of transcriptomics and metabolomics reveal pathway of vacuolar Sur7 contributed to biocontrol potential of entomopathogenic Beauveria bassiana. J Invertebr Pathol. 2021. 181:107564. doi: 10.1016/j.jip.2021.107564. JCR 一区

2. Zhang BL^*, Qiu TT, Yang WWJ. Bioinformatic analysis reveals the distinct role of 5’UTR-specific m6A RNA modification in mice developing cerebral cortices. Dev Neurosci. 2022. doi: 10.1159/000521620. JCR 二区

3. Zhang LB^*, Qiu TT, Huang ZH, Ye XY, Guan Y^*. Transcriptomic analysis of Sur7-mediated response of Beauveria bassiana to different nutritional conditions. FEMS Microbiol Lett. 2021. 368 (3): fnab003. JCR 三区

4. Zhang LB, Tang L, Guan Y, Feng MG^*. Subcellular localization of Sur7 and its pleiotropic effect on cell wall integrity, multiple stress responses, and virulence of Beauveria bassiana. Appl. Microbiol. Biotechnol. 2020. 104 (15): 6669-6678. JCR 二区

5. Zhang LB, Du KZ, Wang J, Nie YZ, Lee T, Sun T^*. Unique and specific m⁶A RNA methylation in mouse embryonic and postnatal cerebral cortices. Genes (Basel). 2020. 11 (10): E1139. JCR 二区

6. Zhang LB, Feng MG^*. Antioxidant enzymes and their contributions to biological control potential of fungal insect pathogens. Appl. Microbiol. Biotechnol. 2018. 102 (12): 4995-5004. (Review) JCR 二区

7. Zhang LB, Tang L, Ying SH, Feng MG*. Two eisosome proteins play opposite roles in autophagic control and sustain cell integrity, function and pathogenicity in Beauveria bassiana. Environ Microbiol. 2017. 19 (5):2037-2052. JCR 一区

8. Zhang LB^#, Mubarak T^#, Chen Y^#, Lee T, Pollock A, Sun T^*. Counter-balance between Gli3 and miR-7 is required for proper morphogenesis and size control of the mouse brain. Front. Cellular Neurosci. 2018. 12:259. JCR 二区

9. Zhang LB, Tang L, Ying SH, Feng MG^*. Distinct roles of cytoplasmic thioredoxin reductases (Trr1/Trr2) in the redox system involving cysteine synthesis and host infection of Beauveria bassiana. Appl. Microbiol. Biotechnol. 2016. 100 (24): 10363-10374.

10. Zhang LB, Tang L, Ying SH, Feng MG^*. Regulative roles of glutathione reductase and four glutaredoxins in glutathione redox, antioxidant activity, and iron homeostasis of Beauveria bassiana. Appl. Microbiol. Biotechnol. 2016. 100 (13): 5907-5917.

11. Zhang LB, Tang L, Ying SH, Feng MG^*. Subcellular localization of six thioredoxins and their antioxidant activity and contributions to biological control potential in Beauveria bassiana. Fungal Genet. Biol. 2014. 76: 1–9. JCR 二区

12. Zhang HJ^#, Zhang LB^#, Sun T^*. Cohesive regulation of neural progenitor development by microRNA miR-26, its host gene Ctdsp and target gene Emx2 in the mouse embryonic cerebral cortex. Front. Mol. Neurosci. 2018. 11: 44. JCR 二区

13. Du KZ, Zhang LB, Sun T^*. m6A RNA methylation controls neural development and is involved in human diseases. Mol. Neurobiol. 2018. 56 (3): 1596-1606. (高被引论文) JCR 一区

14. Hussain G, Zhang LB, Rasul A, Anwar H, Sohail MU, Razzaq A, Aziz N, Shabbir A, Ali M, Sun T^*. Role of plant-derived flavonoids and their mechanism in attenuation of Alzheimer’s and Parkinson’s Diseases: An update of recent data. Molecules. 2018. 23 (4): 814. JCR 二区

15. Floris G, Zhang LB, Follesa P, Sun T^*. Regulatory role of circular RNAs and neurological disorders. Mol Neurobiol. 2017. 24 (7): 5156-5165.

16. Wang ZL, Zhang LB, Feng MG^*. Catalases play differentiated roles in the adaptation of a fungal entomopathogen to environmental stresses. Environ. Microbiol. 2013. 15 (2): 409-418.

17. Nie YZ, Tian GG, Zhang LB, Trevor L, Zhang Z, Li J, Sun T^*. Identifying cortical specific long noncoding RNAs modified by m6A RNA methylation in mouse brains. Epigenetics. 2020. 23: 1-17.

18. Zhang HJ., Chang YF, Zhang LB, Kim SN, Otaegi G, Zhang Z, Nie YZ, Mubarak T, Li C, Qin CF, Xu ZH, Sun T^*. Upregulation of microRNA miR-9 is associated with microcephaly and Zika virus infection in mice. Mol Neurobiol. 2019.56 (6): 4072-4085.

19. Li F, Wang ZL, Zhang LB, Ying SH, Feng MG^*. The role of three calcineurin subunits and a related transcription factor (Crz1) in conidiation, multistress tolerance and virulence in Beauveria bassiana. Appl. Microbiol. Biotechnol. 2015. 99 (2): 827-840.

获奖情况：

福州大学教学创新大赛 一等奖；

其他：