职称：副教授、硕士生导师

学历：博士研究生

电话：14759759282

电子邮件：juanyang@fzu.edu.cn

研究方向：蛋白质化学 结构生物学

教育工作经历：

2019.06—至今     福州大学，bet356体育亚洲官网入口   副教授

2015.05—2019.05  福州大学，bet356体育亚洲官网入口   讲师

2011.09—2015.04  厦门大学，化学生物学专业理学   博士

2011.04—2011.09  中国科学院上海药物研究所交流学习

2008.09—2011.03  华东理工大学，制药工程与技术专业工学  硕士

2004.09—2008.07  郑州大学，制药工程专业工学      学士

教学简介：

讲授本科生课程：《基因工程》、《结构生物学》和《常用生物工程软件应用》

承担本科生实验课程：《免疫组化实验》

科研简介：

主要从事疾病相关的蛋白质靶点与药物之间相互作用的构效关系及药物调控机制的研究，将结构生物学、分子生物学、细胞生物学与生物化学等研究手段相结合，从药物与靶标的构效关系、药物作用的生理和病理机制以及药物调控的分子机理等方面开展研究，为新药的研发提供结构基础和理论指导。目前已在Molecular Microbiology，Org.Lett.，Synthesis，J.Med.Chem.，Nat. Prod. Bioprospect，Protein expression and purification，Acta Biochim Biophys Sin等国际学术期刊上发表SCI论文多篇，并获得国内发明专利两项。

科研项目：

1. 国家自然科学基金（青年基金），人源程序性死亡受体PD-1与其配体PD-L2负性调控免疫应答的结构基础研究，项目编号31700656，项目起止时间2018.01—2020.12，主持；

2. 福建省自然科学基金（青年基金），人程序性死亡配体PD-1与其配体PD-L2调节免疫应答的结构基础和功能研究，项目编号2017J05050，项目起止时间 2017.04-2020.04，主持；

3. 福州大学校人才项目，人源B7家族PD-1-PD-L2通路调节免疫应答的结构基础，项目起止时间2015.5—2017.5，主持。

代表性论文：（*为通讯作者）

1. Juanjuan Yang, Jing Hong, Ling Luo, Ke Liu, Chun Meng, Zhi-liang Ji, Donghai Lin*. Biophysical characterization and ligand-binding properties of the elongation factor Tu from Mycobacterium tuberculosis. Acta Biochim Biophys Sin, 2019, 51(2):139-149.

2. Yunbao Zhi, Yazhuang Dai, Juanjuan Yang, Shuhua Tan, Donghai Lin, Kejiang Lin*. Lead compounds and key residues of ribosomal protein S1 in drug-resistant Mycobacterium tuberculosis.Bioorganic Chemistry, 2019, 82: 58-67.

3. Yang Yang, Zhen Liu, Xiaoqin He, Juanjuan Yang, Jing Wu, Hailong Yang, Min Li, Qian Qian, Ren Lai*, Wei Xu* and Lin Wei*. A small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities. Journal of Biological Chemistry, 2019, 294(19): 7615-7631.

4. Taotao Chen, Zheng Chen, Huimin Wang, Xiaodong Chen, Juanjuan Yang, Aidong Han, Dong-Hai Lin, Jing Hong*. Underlying action mechanism of a novel antioxidant peptide derived from Allium tuberosum Rottler protein hydrolysates and its protective effects on hydrogen peroxide induced cell injury. Journal of Functional Foods, 2018, 40: 606-613.

5. Juanjuan Yang, Yindi Liu, Shuli Xu, Haiying Lin, Chun Meng, Donghai Lin*. Expression, purification and characterization of the full-length SmpB protein from Mycobacterium tuberculosis. Protein expression and purification, 2018, 151: 9-17.

6. Juanjuan Yang, Lei Hu, Tiantian Cai, Qiuluan Chen, Qian Ma, Jie Yang, Chun Meng, Jing Hong*. Purification and identification of two novel antioxidant peptides from perilla (Perilla Frutescens L. Britton) seed protein hydrolysates. PLoS One, 2018, 13(7): 1-15.  

7. Lixian Mu, Lei Zhou, Juanjuan Yang, Li Zhuang, Jing Tang, Tong Liu, Jing Wu, Hailong Yang*. The first identified cathelicidin from tree frogs possesses anti‑inflammatory and partial LPS neutralization activities. Amino Acids, 2017, 49: 1571-1585.

8. Juanjuan Yang, Yindi Liu, Zhao Liu, Chun Meng, Donghai Lin*. Backbone and side-chain resonance assignments for the tmRNA binding protein, SmpB, from Mycobacterium tuberculosis. Biomolecular NMR Assignments, 2017, 11(2): 175-179.

9. Juanjuan Yang, Yindi Liu, Jing Bi, Qixu Cai, Xinli Liao, Wenqian Li, Chenyun Guo, Qian Zhang, Tianwei Lin, Yufen Zhao, Honghai Wang, Jun Liu*, Xuelian Zhang*, Donghai Lin*. Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide. Molecular Microbiology, 2015, 95(5), 791-803. 

10. Lin Wei, Chunjing Huang, Hailong Yang, Min Li, Juanjuan Yang, Xue Qiao, Lixian Mu, Fei Xiong, Jing Wu*, Wei Xu*. A potent anti-inflammatory peptide from the salivary glands of horsefly. Parasit Vectors, 2015, 8: 556-556.

11. Lin Wei§, Juanjuan Yang^§, Xiaoqin He, Guoxiang Mo, Jing Hong, Xiuwen Yan*, Donghai Lin*, Ren Lai*. Structure and Function of a Potent Lipopolysaccharide-Binding Antimicrobial and Anti-inflammatory Peptide. J. Med.Chem. 2013, 56: 3546-3556(§, co-first author).

12.  Li Dong^§, JuanJuan Yang^§, Ying Wang, Huan Liu, LiXian Mu, Donghai Lin*, Ren Lai*. Structure-function  relationship  of  antimicrobial  peptide cathelicidin Pc-CATh7. Nat. Prod. Bioprospect., 2012, 2: 81–86 (§, co-first author).

13. Juanjuan Yang, Huicai Huang,  Zhichao Jin, Wenbin Wu, Jinxing Ye*. Diastereoselective Synthesis of Bicyclo[2.2.2]octan-2-one Derivatives through an Unexpected Organocatalytic Tandem Michael–Michael Reaction. Synthesis, 2011, 12: 1984-1987. 

14. Wenjun Li, Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye. As*, Asymmetric Direct Michael Addition of Acetophenone to α, β-Unsaturated Aldehyde. Synthesis, 2011, 7:1085-1091.

15. Juanjuan Yang, Wenjun Li, Zhichao Jin, Xinmiao Liang, Jinxing Ye*. Enantioselective  Michael  Reaction  of α-Alkyl-β-keto Esters and Enones under Multifunctional Catalysis. Org. Lett., 2010, 12: 5218-5221.

16. Chunlin Wu, Wenjun Li, Juanjuan Yang, Xinmiao Liang*, Jinxing Ye*. Asymmetric organocatalytic Michael addition of anthrone to enone, Org. Biomol. Chem., 2010, 8: 3244-3250.

专利申请：

1. 一种人源程序性死亡受体hPD-1单克隆抗体：杨娟娟，孟春，吕唯，刘照，吴茂，授权专利号 ZL 201611197005.3。

2. 一种人源程序性死亡因子配体hPD-L2单克隆抗体：杨娟娟，孟春，刘照，罗岭，夏菁潞，徐淑丽授权专利号：2017102780143。

获奖情况

1. 2018.11 bet356体育亚洲官网入口 青年教师“最佳一节课”教学竞赛三等奖

2. 2017.11 指导全国大学生生命科学竞赛 获得三等奖

3. 2017.06 福州大学优秀本科毕业论文指导老师